The council’s planning committee granted SRG Estates planning permission at a meeting on Tuesday morning.
The plans include a hotel with conference and leisure facilities, office accommodation and retail and restaurant space, as well as storage and distribution warehousing and landscaping.
The huge 230 hectare site is three kilometres north of Douglas with the Dewars drinks facility at Poneil to the south.
It is estimated that the plans would equal an injection of £33 million into the local economy with a further £18.8 million pumped into the national economy.
For more information on this story, pick up a copy of this week’s Carluke and Lanark Gazette which is in the shops now.