Around 8.15pm on Tuesday evening, police were called to a report of a large-scale disturbance between Overlee Park and Netherton Braes.
Police and ambulance attended and two 16 year-old boys were found injured.
Both have been taken to the Queen Elizabeth University Hospital where one is being treated for a stab wound, and the other is being treated for a head injury.
Detective Sergeant Gordon Walker said: “Our investigation is at an early stage to establish more information on those involved in this disturbance, and officers are currently carrying out enquiries in the area to gather more details on the incident.
“Anyone with information that may be able to assist officers is asked to contact Helen Street Police Office through 101 quoting incident number 3675 of 7th August.
Alternatively Crimestoppers can be contacted on 0800 555 111, where anonymity can be maintained.”