Biggar – whose scheduled home league game against Highland last weekend was postponed after a Covid outbreak in the opposition camp – go into the game second, three points behind Heriot’s with a game in hand.
Third-placed Gala are two points adrift of Biggar, having played a game fewer.
Biggar secretary Mike Booth said the players are highly motivated to win the league after being cruelly denied it two seasons ago, when they were top but the unfinished campaign was null and voided because of, coronavirus.
“Winning this Saturday would strike a psychological blow,” Booth said. "I think we’ve a point to prove and it would be great if we could do it.
"The players really did feel they were robbed that season. And that momentum I’m sure would have led to us being well up in the Premiership as well. The Heriot’s match could be the turning point."
The only Biggar side in action last weekend were the S1s, who lost 30-7 at West of Scotland.
Other fixtures this weekend: Saturday, 2nd XV v Boroughmuir Tennents East Reserve 1 (H) KO 3pm. Sunday, Micro training 10am, Mini v Dumfries (H) KO tbc; Boys Youth, U13 v East Kilbride (H) KO tbc, U15 v Cambuslang (H) KO tbc, U16 v East Kilbride (A) West Youth Cup KO tbc; Girls Youth, U18 v Edinburgh Harlequins (A) KO tbc, U16 v Stirling County National Youth Cup (A) KO tbc.