The two sides currently sit in second and third place respectively, even on 56 points.
The winner will position themselves in second place — making them favourites to be top seed for the playoffs.
The match kicks off at 12.45pm at Hampden.
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On Saturday Scott Gibson popped up to net his first goal for Queen’s — and it was enough to seal a 2-1 away victory for the Spiders at Montrose.
The downside of the afternoon was a red card for Giuseppe Capuano.
Lok crashed out of the New Coin Holdings West of Scotland Cup in the third round on penalties.
A 2-2 draw after extra time against Largs Thistle was followed by bitter disappointment when Lok went down 5-4 from the spot.
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However, last Wednesday, Pollok claimed a quarter-final berth in the Euroscot Engineering Central League Cup with a penalty shoot-out victory against Kirkintilloch Rob Roy at Adamslie Park.