The company which first opened in Wardpark in September 1987 has announced it is to move all its manufacturing to Asia with the loss of 131 jobs.
In 2013 OKI, which makes printers and telecommunications equipment, axed 175 jobs at its Cumbernauld plant.
However, the future for the remaining workers looked to have been secured when it moved its base to the former Patak’s factory in Westfield in March 2014.
Now though it has been confirmed that production will end by the end of the year and the site will be closed by March.
A spokeswoman said: “OKI Data Corporation has taken the decision to consolidate the manufacturing of toner and ribbons globally to our factories in Asia.
“Sadly, this will result in the closure of the OKI Cumbernauld manufacturing facility. We expect production at the site to conclude in December 2018 and the planned site closure to be completed by the end of March 2019.
“This difficult decision was taken due to a declining market resulting in surplus manufacturing resource.
“We are aware this will be a significant blow to our staff and to the local community in Cumbernauld and as we enter a period of consultation, our priority is to support affected employees whilst we go through this difficult process and no further details can be provided at this time.”
Cumbernauld’s MSP Jamie Hepburn and MP Stuart McDonald were both saddened by the news and offered their support to the affected staff.
Mr Hepburn said: “OKI closing up shop is sad news for Cumbernauld. They have been associated with the town for a long time and that this association is coming to an end is very disappointing.
“They have of course been reducing their presence over a significant period of time, and the important thing now is that the company does everything it can to support the remaining workforce through the process of closure.
“The Scottish Government’s Partnership Action for Continuing Employment will do everything it can to help.”
Mr McDonald added: “This is clearly very distressing news for the workers at the site, many of whom stay locally.
“I am aware that the Scottish Government’s Partnership Action for Continuing Employment (PACE), is now involved to support the workforce and ensure that they are able find new opportunities as quickly as possible.
“I am of course happy to assist any of my constituents who are directly affected in whatever way I can.”