The £250,000 project, being carried out by contractor Clancy Docwra, will see the repair and replacement of sections of mains in the Luggie Road area of the town.
Work will start on Monday, October 23, and it is expected to last for around five weeks.
Roadworks will be required for the duration of the work, with temporary traffic lights in place, and there may be some parking and access restrictions.
Ruaridh MacGregor, of Scottish Water, said: “This essential work is taking place over the next five weeks in the Luggie Road area to help ensure customers can continue to enjoy clean, fresh drinking water long into the future.
“The traffic management is put in place in full consultation with South Lanarkshire Council.
“The temporary traffic lights will help ensure any disruption for road users is kept to an absolute minimum.
“We want to thank customers for their patience and understanding as this essential work takes place over the coming weeks.”