Carluke Rovers will be hoping to put their poor start in the league to one side when they face Beith while Lanark United face a tricky home tie against Kilbirnie at Moor Park.
Forth Wanderers travel to Wishaw who recently lost their manager John McKeown to Cumnock and Lesmahagow will want to continue their good form when they face Cumbernauld.
All four games kick-off at 2pm.